Both Radiesse and Sculptra Aesthetic have specific indications for where on the face they should be used. Unlike hyaluronic acid fillers, they should never be used in the lips or in small lines around the lips. “The only places where these should be injected are in the jowls, nasolabial folds, marionette lines and chin wrinkles. These products are not line fillers but they do restore collagen and add volume. On occasion, when used in inappropriate places, lumps and bumps can form, which has been described as being similar to the pain associated with cystic acne.