Real collagen stimulators may provide some initial filling effect due to the fluid that surrounds the microscopic particles in the product (these prompt collagen to be made). “During the first 24 hours after injections, the fluid gets absorbed and the fullness that you initially see may start to dissipate. It takes time to stimulate new collagen for the full effects to show in the face, which can take a few months and a few treatment sessions.

This is not true. Although hyaluronic acid wasn’t formulated to do so, science has proven they can create collagen. But many doctors agree that the amount of collagen made is not as much of collagen made is not as you can expect from products that are specifically formulated to create collagen. The function of collagen-stimulating fillers is to create collagen. Hyaluronic acid fillers add fullness. “With a hyaluronic acid filler, the collagen effect is modest when compared to a collagen stimulator,” says Dr. Calkin.

Both Radiesse and Sculptra Aesthetic have specific indications for where on the face they should be used. Unlike hyaluronic acid fillers, they should never be used in the lips or in small lines around the lips. “The only places where these should be injected are in the jowls, nasolabial folds, marionette lines and chin wrinkles. These products are not line fillers but they do restore collagen and add volume. On occasion, when used in inappropriate places, lumps and bumps can form, which has been described as being similar to the pain associated with cystic acne.

• It is rarely recommended that you use straight black for an eyebrow procedure unless a stark black is the only color that will show up after healing on an extremely dark skin tone.
• This is rare, as we do not want to operate in absolutes as the ability to adjust on the follow-up visit is reduced.

• Needle configuration.
• The smaller needle configuration the more ash will appear when healed.

• For eyebrow tattoos, a cosmetic tattooing machine is used to implant pigment into your skin with a variety of tiny needles. The difference is that with a regular tattoo machine the pigment is implanted much closer to the skin’s surface as compared to the eyebrow microblading pen.
• Microblading uses a handheld tool known as a microblading pen instead of a motorized tattooing machine.
• The difference with microblading is that the technique can achieve hair-like strokes to create the illusion of actual hairs, whereas eyebrow tattoos are more block-like in their end result to make it look as though the eyebrow has been colored in with a brow pencil or powder.
• Microblading involves the meticulous drawing of each hair stroke following the direction and length of the existing hairs.
• Microblading implants the pigment, which is close to the skin, to create the look of realistic fine hairs, creating a more natural look than eyebrow tattoos. However, eyebrow tattoos may last longer as the eyebrow pen more solidly draws the pigment into the skin, as well as inserts it into deeper layers.

a. Generally, microblading can last anywhere from 1 to 3 years. The initial service includes a follow up visit for minor tweaking within 3-4 weeks of the service. A touch up is recommended after 18 months or possibly sooner if required. b. Since this is a semi-permanent treatment some fading will occur, however, that depends on your skin type and lifestyle. For example, if you lead an outdoor lifestyle spending a lot of time in the sun the pigment may fade sooner.

a. The microblading healing process generally takes 25 to 30 days. However, duration of the healing process will be slightly different for each person. It depends on many factors, including your: i. age ii. overall health iii. skin type b. In general, during the first 10 to 14 days the appearance of your eyebrows, color, definition, and texture will change almost every day. c. You’ll also experience different sensations in your skin. At first, your face will feel tender, tight, and painful. This will turn into itchiness and flaking, which eventually subsides. d. Touchups that are done every 12 to 18 months, also have some healing time.

Green bases are more ideal for ruddy or red-based skin tones.

Red or orange bases are more ideal for blue, and yellow for violet skin tones.

Browns

As a tip for avoiding gray brows, it never hurts to put a drop or two of an ochre in a brown to ward off the grays which can be brought on by an ash skin tone that is not easily recognized. This is an insurance technique much like we use with orange added to a lip pigment to avoid a lip healing too blue.

• Your provider will know to start the eyebrow procedure with a pigment that tends to be lighter or cool (green or yellow/green), this is a safe, moderate approach.
• At the follow-up visit, the depth and temperature of the color of this brow can be modified more easily rather than having a brow healed too dark and too warm (red, or red/yellow = orange.

Pigment that remains closer to the surface of the skin will be exposed to more light and appear less cool than pigment that resides deeper in the skin.

• It is one that has faded to an orange, gray or blue tone

• 1 year prior
  • No use of Accutane for at least 1 year prior
• 4 months prior
  • Do not use retinol products
• 4 weeks prior
  • Do not have botox, chemical peels 3 weeks prior.
  • Do not undergo laser treatments
• 3 weeks prior
  • Do not tan two weeks prior or have sunburned face/skin.
• 2 weeks prior
  • Do not have any type of facial 2 weeks prior to treatment.
• 1 week prior
  • Do not pick/thread/tweeze/wax/perform electrolysis one week before the procedure.
  • Do not get exposed to heavy sunlight, especially sunburn
• 2 days prior
  • DO NOT take Aspirin, Niacin, Vitamin E and/or Ibuprofen, omega-3, unless medically necessary (Tylenol or Acetaminophen is okay!)
  • For any Lip treatment, you must STOP USING Valtrex
  • For any Lip treatment, keep lips moisturize at all times prior to appointment
• Day of treatment
  • Do not drink alcohol or coffee as these can lead to thinning of blood
    • The recommended waiting time between the consumption of alcoholic or caffeinated products prior to a permanent makeup treatment is 24 hours (the night before definitely still counts!).
  • Do not work out the day of the procedure.

• Follow-up
  • Plan on follow up 2 – 6 months after treatment
• Up to 4 – 6 weeks
  • No swimming until the area is completely healed, salt water/chlorine can cause the pigments to fade or change in color.
  • It is recommended to apply the Vaseline to the treated area/s prior to swimming even after healed to prevent the chlorine water/salt water from penetrating the area.
• Up to 5 weeks after
  • Do not use any products with retinol-A.
• Up to 4 weeks after
  • Avoid facials, chemical peels, or microdermabrasion for 4 weeks.
• Up to 2 weeks after
  • Avoid direct sunlight or tanning beds for 2 weeks after the tattoo.
  • Avoid Botox or acid peels
• Up to 10 days after
  • Avoid hot tubs, steam rooms, public pools, sweaty exercise, or submerging the tattoo in water for the first 10 days.
• Up to 1 week after
  • Avoid putting makeup on the area for the first week.
  • Avoidance of alcohol will help the immune system and improve the healing process.
  • Avoid sleeping on your face

Black brown pigments will serve the eyebrow client much better than a straight black because straight black may fade to blue or gray tone overtime

A technician will use a sharp blade to cut tiny hair-like strokes into the brow bone during the tattoo-esque experience to imitate natural hair and deposit pigment underneath the skin, so it is vitally important that the skin can handle treatment in this region.

Retinol is a type of vitamin A found in many skin care products. Please review the products you use in your skincare regimen. The benefit of retinol is that it increases in the development of collagen, which is the number one anti-aging ally.

However, the greatest drawback though is the fact that it dries up the skin and makes it flaky, which will make your microblading fade. The earlier new skin cells replace old skin cells, the faster they disappear. Frequent retinol use reduces the duration of this procedure by half.

It is also advised that exfoliating acids or retinol should not be used before microblading for at least four weeks. During microblading, acids and retinol may thin or sensitize your skin and may cause your skin to tear and aggravate.

• Your natural eyebrow hairs will continue to grow outside of the treatment area. This means that you will still need to pluck the occasional stray hair (depending on your own hair growth).
• If you have rather lustrous and bushy brows, then you may have to have these shaped every so often. One benefit of the service is that is provides a perfect guide for touching up.
• Speak to your provider if you have naturally light-colored eyebrow hairs and the pigment from your microblading is significantly darker to discuss periodic touchups.
• Also, consider that dying may not be immediately recommended soon after the procedure as eyebrow dye can irritate the microbladed area.

Microblading does not generally have an effect on your natural hair growth. The procedure does neither, prevent any progressive hair loss or encourage the growth.

a. Eyebrows will gradually fade over time. The general consensus is that the color fades by roughly 50% in a year or more. b. However, some see fading within a few months, while in others it may last for a few years. c. How your microblading wounds heal and how long the results last will depend entirely on your body.

• 1 year prior
  • No use of Accutane for at least 1 year prior
• 4 months prior
  • Do not use retinol products
• 4 weeks prior
  • Do not have botox, chemical peels 3 weeks prior.
  • Do not undergo laser treatments
• 3 weeks prior
  • Do not tan two weeks prior or have sunburned face/skin.
• 2 weeks prior
  • Do not have any type of facial 2 weeks prior to treatment.
• 1 week prior
  • Do not pick/thread/tweeze/wax/perform electrolysis one week before the procedure.
  • Do not get exposed to heavy sunlight, especially sunburn
• 2 days prior
  • DO NOT take Aspirin, Niacin, Vitamin E and/or Ibuprofen, omega-3, unless medically necessary (Tylenol or Acetaminophen is okay!)
  • For any Lip treatment, you must STOP USING Valtrex
  • For any Lip treatment, keep lips moisturize at all times prior to appointment
• Day of treatment
  • Do not drink alcohol or coffee as these can lead to thinning of blood
    • The recommended waiting time between the consumption of alcoholic or caffeinated products prior to a permanent makeup treatment is 24 hours (the night before definitely still counts!).
  • Do not work out the day of the procedure.

• Follow-up
  • Plan on follow up 2 – 6 months after treatment
• Up to 4 – 6 weeks
  • No swimming until the area is completely healed, salt water/chlorine can cause the pigments to fade or change in color.
  • It is recommended to apply the Vaseline to the treated area/s prior to swimming even after healed to prevent the chlorine water/salt water from penetrating the area.
• Up to 5 weeks after
  • Do not use any products with retinol-A.
• Up to 4 weeks after
  • Avoid facials, chemical peels, or microdermabrasion for 4 weeks.
• Up to 2 weeks after
  • Avoid direct sunlight or tanning beds for 2 weeks after the tattoo.
  • Avoid Botox or acid peels
• Up to 10 days after
  • Avoid hot tubs, steam rooms, public pools, sweaty exercise, or submerging the tattoo in water for the first 10 days.
• Up to 1 week after
  • Avoid putting makeup on the area for the first week.
  • Avoidance of alcohol will help the immune system and improve the healing process.
  • Avoid sleeping on your face

A technician will use a sharp blade to cut tiny hair-like strokes into the brow bone during the tattoo-esque experience to imitate natural hair and deposit pigment underneath the skin, so it is vitally important that the skin can handle treatment in this region.

Retinol is a type of vitamin A found in many skin care products. Please review the products you use in your skincare regimen. The benefit of retinol is that it increases in the development of collagen, which is the number one anti-aging ally.

However, the greatest drawback though is the fact that it dries up the skin and makes it flaky, which will make your microblading fade. The earlier new skin cells replace old skin cells, the faster they disappear. Frequent retinol use reduces the duration of this procedure by half.

It is also advised that exfoliating acids or retinol should not be used before microblading for at least four weeks. During microblading, acids and retinol may thin or sensitize your skin and may cause your skin to tear and aggravate.

Ultimately you should take into consideration the age of the patient, the treatment area and what we are trying to achieve.

PDO threads are better at repositioning and revitalizing tissue but not for providing lift so would be suited more to younger patients.

PLA threads provide some lifting, but again would be suitable for patients who only require a small amount of tissue lift.

PCA threads provide more lift and are more suitable for patients who require a small to moderate amount of lift. Other factors that have an effect on the desired results are the technique used to insert the threads and the positioning of the threads

There are three types of threads, PDO (Polydioxanone), PLA (polylactic acid), and PCA (polycaprolactone). PLA and PCA threads are newer than PDO. PDO threads have been around the longest, since the 1980s.

They are made from a colorless polyester that breaks down in your body after about 6 months.

PLA and PCA threads last longer and tend to stimulate more collagen production.

PLA threads take about 12 months to be absorbed and PCA takes about 12 to 15 months.

Each type of thread is best suited for a particular benefit. PDO threads are better at repositing and revitalizing tissue while PLA and PCA threads are better at lifting sagging parts of your skin.

PCA threads are the newest threads and are bio-absorbable, monofilament suspension threads of synthetic origin (caprolactone).

They work by regenerating collagen over a longer time than PDO and PLA threads. They leave behind a collagen structure that provides support for the skin, tightens the skin and prevents it from sagging.

Due to the fibrotic reaction caused by the threads, the lifting and stretching action will continue even after the threads have been resorbed. The process of thread breakdown produces molecules of small molecular weight which subsequently induce the production of collagen and Hyaluronic acid by the skin.

The resulting skin is more moisturized, revitalized and firm with a long lasting result.

There are three main types of threads, polydioxanone (PDO), polylactic acid (PLA) and polycaprolactone (PCA). PDO threads have been around the longest, hence the term PDO Threads may often be used as a generic term for this product.

PDO threads have been around since the 1980s and are made of a synthetic biodegradable polymer that has been used in surgery for many years. PDO threads are absorbed into the body over 6 months by hydrolysis and work by triggering fibroblasts to produce more collagen in a targeted area.

There are three main types of PDO threads used;

1. mono,
2. cog and
3. screw threads.

Mono threads are smooth without barbs and are anchored to a point on the face or the scalp. They mainly tighten the skin and provide a small amount of lift.²

Cog threads have barbs which hook onto the skin to provide support and lift the sagging tissue.

Screw threads have one or two intertwined threads around the needle and provide good volume restoration to sunken areas of the skin. The production of collagen around the threads and their barbs helps to restore volume and improves the skin texture and elasticity resulting in a natural aesthetics outcome.

There are three types of threads lifts, PDO (Polydioxanone), PLA (polylactic acid), and PCA (polycaprolactone). PLA and PCA threads are newer than PDO Threads.

It is important to seek medical attention as soon as possible if you suspect that a thread has broken during the procedure.

When a PDO thread snaps, patients can feel a sudden sharp pain, which is often accompanied by a popping or cracking sound. This occurs due to the sudden release of tension in the thread.

The threads may break due to excess facial movement, rubbing the skin, or exposure to moisture. When it does happen, breakage tends to be near the ends near the incision point. The broken thread poses no threat to you. The piece may migrate up until it extrudes from the skin.

If the thread has become extruded it may be possible to simply remove it, otherwise you may have to have it surgically removed, possibly through a facelift incision.

PDO threading is a procedure that uses a dissolvable suture to tighten and lift your skin. It reduces wrinkles and fine lines. The amazing thing is that these threads trigger the (fibroblast) cells in your body to produce more collagen which in turn gives your skin its structure and elasticity to provide an anti-aging effect.

Permanent makeup (PMU) is referred to by several terms including semi-permanent makeup, cosmetic tattoo or micropigmentation. I

Permanent Makeup for lipst is done with the use of a pen containing iron oxide that tattoos the skin and to provide the appearance of makeup. This tattoo technique can also mimic eyeliner or lipstick, or it can darken and create the look of thicker eyebrows.

• 1 year prior
  • No use of Accutane for at least 1 year prior
• 4 months prior
  • Do not use retinol products
• 4 weeks prior
  • Do not have botox, chemical peels 3 weeks prior.
  • Do not undergo laser treatments
• 3 weeks prior
  • Do not tan two weeks prior or have sunburned face/skin.
• 2 weeks prior
  • Do not have any type of facial 2 weeks prior to treatment.
• 1 week prior
  • Do not pick/thread/tweeze/wax/perform electrolysis one week before the procedure.
  • Do not get exposed to heavy sunlight, especially sunburn
• 2 days prior
  • DO NOT take Aspirin, Niacin, Vitamin E and/or Ibuprofen, omega-3, unless medically necessary (Tylenol or Acetaminophen is okay!)
  • For any Lip treatment, you must STOP USING Valtrex
  • For any Lip treatment, keep lips moisturize at all times prior to appointment
• Day of treatment
  • Do not drink alcohol or coffee as these can lead to thinning of blood
    • The recommended waiting time between the consumption of alcoholic or caffeinated products prior to a permanent makeup treatment is 24 hours (the night before definitely still counts!).
  • Do not work out the day of the procedure.

• Follow-up
  • Plan on follow up 2 – 6 months after treatment
• Up to 4 – 6 weeks
  • No swimming until the area is completely healed, salt water/chlorine can cause the pigments to fade or change in color.
  • It is recommended to apply the Vaseline to the treated area/s prior to swimming even after healed to prevent the chlorine water/salt water from penetrating the area.
• Up to 5 weeks after
  • Do not use any products with retinol-A.
• Up to 4 weeks after
  • Avoid facials, chemical peels, or microdermabrasion for 4 weeks.
• Up to 2 weeks after
  • Avoid direct sunlight or tanning beds for 2 weeks after the tattoo.
  • Avoid Botox or acid peels
• Up to 10 days after
  • Avoid hot tubs, steam rooms, public pools, sweaty exercise, or submerging the tattoo in water for the first 10 days.
• Up to 1 week after
  • Avoid putting makeup on the area for the first week.
  • Avoidance of alcohol will help the immune system and improve the healing process.
  • Avoid sleeping on your face

A technician will use a sharp blade to cut tiny hair-like strokes into the brow bone during the tattoo-esque experience to imitate natural hair and deposit pigment underneath the skin, so it is vitally important that the skin can handle treatment in this region.

Retinol is a type of vitamin A found in many skin care products. Please review the products you use in your skincare regimen. The benefit of retinol is that it increases in the development of collagen, which is the number one anti-aging ally.

However, the greatest drawback though is the fact that it dries up the skin and makes it flaky, which will make your microblading fade. The earlier new skin cells replace old skin cells, the faster they disappear. Frequent retinol use reduces the duration of this procedure by half.

It is also advised that exfoliating acids or retinol should not be used before microblading for at least four weeks. During microblading, acids and retinol may thin or sensitize your skin and may cause your skin to tear and aggravate.

Unfortunately, we do not accept insurance for the weight loss program at this time.

To schedule a Telehealth or in-office visit, you can click on the Book An Appointment, or call us at (954)526-2686.

Semaglutide is dispensed by our contracted pharmacy. If our office is selected as the final delivery destination, Semaglutide will arrive within 4-5 business days. If home delivery is selected, Semaglutide will arrive within 7-10 business days.

It typically takes about two weeks for Semaglutide to start working in the body. While taking Semaglutide, some people begin to see results within the first eight weeks, but most begin to see results within 12 weeks.

Clinical trials have shown that study participants taking a weekly dose of Semaglutide had an average reduction in body weight of 5-10 percent. This means that if you take Semaglutide for a year or more, you may experience up to 15 percent total weight loss.

A medical study of 1961 participants demonstrated that in a 68-week period, participants lost an average body weight of approximately 15%. Furthermore, 1 out of 3 participants lost more than 20% of their body weight.

1. Given the prior evidence and the results reported by Bezin et al. in this issue of Diabetes Care, it is possible that GLP-1 RAs cause a moderate relative increase in thyroid cancer, but detection bias cannot be ruled out as an alternative explanation. Thyroid cancer is a rare outcome, however, and the potential increase in absolute risk is very small.
2. Clinicians and patients need to always balance the benefit and harm of treatments in light of their alternatives.
3. In a population without specific risk factors for thyroid cancer, the benefits of GLP-1 RAs will largely outweigh the harm.

As part of a good weight reduction program and to prevent you from regaining the lost weight you will need to make changes to your day-to-day lifestyle. This includes modifying what you eat.

A good food program creates a healthy, sustainable way of eating that promotes weight loss and sets you up for long-term health. A good program does this by focusing on the quality of foods and making sure your body is getting the building blocks it needs while helping you to feel in-control.

Importantly, this food program is not a diet: We do not use meal replacements or meal plans. We don’t try to restrict your eating. Instead, we will help you rebalance your mindset into a new eating lifestyle.

The potential risk is of thyroid cancer which is already clearly identified in the drug insert.

Semaglutide is part of a class of medications called GLP-1 receptor agonists, or glucagon-like peptide-1 receptor agonists. It increases insulin secretion, which is good for diabetes. But at higher doses, it acts on centers in the brain and suppresses appetite. It is important to use this medication in conjunction with lifestyle intervention. What this medicine does is help patients adhere to a reduced-calorie diet. With obesity, you always need lifestyle changes plus the medicine.”

A safety signal does not necessarily imply a direct causal relationship between a medicine and the reported adverse event.

An assessment is to be initiated to further investigate whether there exists an indication of cause (a link) exists between the medication and the reported adverse event.

Semaglutide, and other drugs in the same category (glucagon-like peptide GLP-1 receptor antagonists), have been available in the market for over a decade. This is according to Andersen-Lange, Novo Nordisk’s products.

Additionally, the safety data gathered from clinical trials and post marketing surveillance have not shown any conclusive evidence linking them to thyroid cancer.

In order to minimize the strong feelings of hunger, our program includes a reverse titration schedule as well. This will help reduce the feelings of hunger and allow time to modify your diet for optimal satiation.

Additional visits to Reflections you will review what is working and what needs to change. You’ll discus some new menu options as well. This will also help reinforce your new eating habits and tweak any changes to help you.

If you miss a dose and the next scheduled dose is more than 2 days away, take the missed dose as soon as possible. If you miss a dose and the next scheduled dose is less than 2 days away, do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses. If you miss your dose for 2 weeks or more, take the next dose at your regular time or call your care team to talk about how to restart this medication.

We do not offer refunds for orders placed, goods received, and/or services rendered.

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, reducing your sense of hunger, prescribed as an adjunct to a healthy diet and exercise regimen for weight loss and management.

Semaglutide can be administered weekly, at any time of day but it should be on the same day each week, with or without meals.

The maintenance dose of Semaglutide is 2.4 mg once weekly.  This dosage is met gradually under the direction of your medical provider.

Your provide will go over interactions as part of your initial consultation. Medications for diabetes are on the list as well as others listed in the full disclosure form.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

1. Obesity is a known factor.
2. Over diagnosis of thyroid cancer.
3. More research is needed to differentiate the causal relationship.

Your provider will review the information sheet which provides full disclosure of known side effects and conditions that would exclude you from getting this treatment. A partial list includes:

• Endocrine tumors (MEN 2) or if someone in your family had these tumors
• Eye disease, vision problems
• Gallbladder disease
• History of depression or mental health disease
• History of pancreatitis
• Kidney disease
• Stomach or intestine problems
• Suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member
• Thyroid cancer or if someone in your family had thyroid cancer
• An unusual or allergic reaction to Semaglutide, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

Attend your scheduled visits with your provider for regular checks on your progress. It may be some time before you see the benefit from this medication.

Be sure to drink plenty of fluids while taking this medication. If you have severe diarrhea, nausea, and vomiting, or if you sweat a lot check in with your provider. The loss of too much body fluid may make it dangerous for you to take this medication.

This medication may affect blood sugar levels. Ask your provider if changes in diet or medications are needed if you have diabetes.

If you or your family notice any changes in your behavior, such as new or worsening depression, thoughts of harming yourself, anxiety, other unusual or disturbing thoughts, or memory loss, call your provider right away.

Losing weight while pregnant is not advised and may cause harm to the unborn child. Talk to your care team for more information .Women should inform their care team if they wish to become pregnant or think they might be pregnant

Side effects tend to come on early in the course of treatment and get better over time. Only infrequently are they serious enough that patients have to stop taking the drug. In practice with the dosage plan, you build up gradually to overcome symptoms. The side effects that you should report to your provider as soon as possible include:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Change in vision
• Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
• Gallbladder problems—severe stomach pain, nausea, vomiting, fever
• Heart palpitations—rapid, pounding, or irregular heartbeat
• Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
• Pancreatitis—severe stomach pain that spreads to your back or gets worse after eating or when touched, fever, nausea, vomiting
• Thoughts of suicide or self-harm, worsening mood, feelings of depression
• Thyroid cancer—new mass or lump in the neck, pain or trouble swallowing, trouble breathing, hoarseness

Side effects that usually do not require medical attention (report to your provider if they continue or are bothersome):

• Diarrhea
• Loss of appetite
• Nausea
• Stomach pain
• Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

If there is a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MENS2) or in case of hypersensitivity to Semaglutide.

Semaglutide should be injected subcutaneously into upper arms, abdomen or thighs.

There are three qualifying categories:

1. Adults with a BMI of 30 or more (obesity category).
2. Adults with a BMI of 27-29 (overweight category), who also have at least one weight-related comorbid condition such as hypertension, diabetes type 2, or hyperlipidedemia.
3. Pediatrics, 12 years and older with a BMI in the 95th percentile or greater.

1. Given the prior evidence and the results reported by Bezin et al. in this issue of Diabetes Care, it is possible that GLP-1 RAs cause a moderate relative increase in thyroid cancer, but detection bias cannot be ruled out as an alternative explanation. Thyroid cancer is a rare outcome, however, and the potential increase in absolute risk is very small.
2. Clinicians and patients need to always balance the benefit and harm of treatments in light of their alternatives.
3. In a population without specific risk factors for thyroid cancer, the benefits of GLP-1 RAs will largely outweigh the harm.

The potential risk is of thyroid cancer which is already clearly identified in the drug insert.

Semaglutide, and other drugs in the same category (glucagon-like peptide GLP-1 receptor antagonists), have been available in the market for over a decade. This is according to Andersen-Lange, Novo Nordisk’s products.

Additionally, the safety data gathered from clinical trials and post marketing surveillance have not shown any conclusive evidence linking them to thyroid cancer.

1. Obesity is a known factor.
2. Over diagnosis of thyroid cancer.
3. More research is needed to differentiate the causal relationship.