What side effects from Semaglutide may I notice?

Side effects tend to come on early in the course of treatment and get better over time. Only infrequently are they serious enough that patients have to stop taking the drug. In practice with the dosage plan, you build up gradually to overcome symptoms. The side effects that you should report to your provider as soon as possible include:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Change in vision
• Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
• Gallbladder problems—severe stomach pain, nausea, vomiting, fever
• Heart palpitations—rapid, pounding, or irregular heartbeat
• Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
• Pancreatitis—severe stomach pain that spreads to your back or gets worse after eating or when touched, fever, nausea, vomiting
• Thoughts of suicide or self-harm, worsening mood, feelings of depression
• Thyroid cancer—new mass or lump in the neck, pain or trouble swallowing, trouble breathing, hoarseness

Side effects that usually do not require medical attention (report to your provider if they continue or are bothersome):

• Diarrhea
• Loss of appetite
• Nausea
• Stomach pain
• Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.